Abstract
O'Connor et al. show that lymphoma cells (LCs) enter the brain but quickly exit along an endothelial CXCL12 gradient, which is countered by astrocyte-derived CCL19. Aged and gliotic brains express more CCL19 and thus retain LCs longer, conferring an increased risk of developing central nervous system lymphoma.
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O’Connor, T., Zhou, X., Kosla, J., Adili, A., Garcia Beccaria, M., Kotsiliti, E., … Heikenwalder, M. (2019). Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention. Cancer Cell, 36(3), 250-267.e9. https://doi.org/10.1016/j.ccell.2019.08.001
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