Decrease of Urinary Taurine in Essential Hypertension

Abstract

In order to evaluate how taurine relates to the pathogenesis of essential hypertension, the taurine content of plasma, whole blood and urine was measured in 18 normals and in 79 hypertensive patients. The patients included 32 untreated cases of essential hypertension, 32 treated cases and 15 cases with labile hypertension. There were no statistically significant differences between normals and essential hypertensives in either plasma or whole blood taurine content. However, in comparison to urinary taurine excretion in normals, 1594.0±143.7 μmol/day (mean±SE), that for untreated essential hypertensives, 708.1±57.1 μmol/day (p<0.001), and for treated essential hypertensives, 953.6±94.3 μmol/day (p<0.001), were significantly lower. Those with labile hypertension showed almost the same value, 1478.3μ134.3 μmol/day, as normals. Taurine clearance and the taurine/creatinine ratio were also markedly decreased in essential hypertensives without treatment. For all subjects, taurine clearance had a positive correlation (r=0.327, p<0.01) with creatinine clearance, but there were significant negative correlations between systolic blood pressure and daily urinary taurine excretion (r=-0.472, p<0.01) and between diastolic blood pressure and daily urinary taurine excretion (r=-0.382, p<0.01). There were also significant positive correlations between daily urinary taurine excretion and serum high-density lipoprotein cholesterol (r=0.559, p<0.01) and between the former and cardiac index (r=0.547, p<0.01). These results suggest that a deficiency of taurine plays an important role not only in elevating blood pressure in essential hypertension but also in atherogenesis as well. © 1983, International Heart Journal Association. All rights reserved.