Cathepsin B contributes to autophagy-related 7 (Atg7)-induced nod-like receptor 3 (NLRP3)-dependent proinflammatory response and aggravates lipotoxicity in rat insulinoma cell line

Abstract

Background: Previous studies show that autophagy deficiency leads to inflammasome activation. Results: Excessive autophagy activation induces a proinflammatory response. Conclusion: Our findings provide new insights into the release mechanisms of proinflammatory cytokines regulated by autophagy. Significance: That autophagy may play a deleterious role in pathogenesis in T2D is a novel finding. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.