Abstract
The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their potential implications on SARS-CoV-2 evolution.
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Mourier, T., Sadykov, M., Carr, M. J., Gonzalez, G., Hall, W. W., & Pain, A. (2021). Host-directed editing of the SARS-CoV-2 genome. Biochemical and Biophysical Research Communications, 538, 35–39. https://doi.org/10.1016/j.bbrc.2020.10.092
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