Abstract
Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-negative bacteria. The conjugate has antimicrobial activity and there is a positive dendritic effect compared to Ciprofloxacin itself.
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CITATION STYLE
Svenningsen, S. W., Frederiksen, R. F., Counil, C., Ficker, M., Leisner, J. J., & Christensen, J. B. (2020). Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate. Molecules, 25(6). https://doi.org/10.3390/molecules25061389
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