Enhancement of cellular glucose uptake by reactive species: A promising approach for diabetes therapy

1Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.

Abstract

It is generally known that antidiabetic activity is associated with an increased level of glucose uptake in adipocytes and skeletal muscle cells. However, the role of exogenous reactive oxygen and nitrogen species (RONS) in muscle development and more importantly in glucose uptake is largely unknown. We investigate the effect of RONS generated by cold atmospheric plasma (CAP) in glucose uptake. We show that the glucose uptake is significantly enhanced in differentiated L6 skeletal muscle cells after CAP treatment. We also observe a significant increase of the intracellular Ca++ and ROS level, without causing toxicity. One of the possible reasons for an elevated level of glucose uptake as well as intracellular ROS and Ca++ ions is probably the increased oxidative stress leading to glucose transport.

Cite

CITATION STYLE

APA

Kumar, N., Shaw, P., Razzokov, J., Yusupov, M., Attri, P., Uhm, H. S., … Bogaerts, A. (2018). Enhancement of cellular glucose uptake by reactive species: A promising approach for diabetes therapy. RSC Advances, 8(18), 9887–9894. https://doi.org/10.1039/c7ra13389h

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free