Aseptic Meningitis after BNT-162b2 COVID-19 Vaccination: Case Report and Literature Review

Abstract

We encountered a-27-year-old female patient who developed refractory severe headache and photo-phobia after the first dose of COVID-19 vaccine. Despite her prior history of migraine, we diagnosed COVID-19 vaccine-induced aseptic meningitis. Symptoms were significantly resolved after methylpred-nisolone therapy. On reviewing the literature, we could find only nine similar cases, with over half of them affecting women aged 20–40 years. Although uncommon, aseptic meningitis should be suspect-ed in patients with persistent or delayed onset of headache following COVID-19 vaccination.