Evaluación de la citotoxicidad inducida por TiO2 modificado funcionalizado con folato y oro sobre líneas celulares de HeLa y CHO

Abstract

The main objective of this work was to determine the photocatalytic effect of the TiO2 mod-FA and TiO2 mod- FA-Au nanomaterials on Hela and CHO line cells. Titanium oxide (TiO2), a substance with possible and future use on the treatment of different cancer types, is analyzed due to its possible cytotoxicity effects when it is exposed to ultraviolet light. The level of cytotoxicity of the nanomaterials in presence and absence of ultraviolet light was determined by the cytotoxicity detection kit. The results showed that the nanomaterials under the established parameters are toxic on Hela cells but non-toxic on CHO cells. The effect of the TiO2 mod-FA-Au nanomaterials exposed over 40 minutes to ultraviolet light showed 78% of cytotoxicity on Hela cells, being the highest percentage between the nanomaterials. The selectivity over cancer cells was the main finding that could become a possible path for cancer treatment with lower secondary effects on human health.