Clinical Trial of Disodium Cromoglycate in Treatment of Asthma in Children

Abstract

A double-blind crossover clinical trial of disodium cromoglycate (Intal) administration by inhalation for the treatment of asthma in 44 children has shown this preparation to have a beneficial effect. There were no ill effects except for occasional soreness of the throat and hoarseness. Some patients who had previously required continuous corticosteroid therapy were able to reduce the dose or to discontinue treatment without clinical deterioration. In most cases no loss of clinical benefit was observed over a three-month period of treatment. Much remains to be learned about the mode of action, the long-term effects, and the selection of suitable subjects for this novel method of treatment. Our results are encouraging and justify further study. © 1968, British Medical Journal Publishing Group. All rights reserved.