Antibiotic resistance determinants of a group of multidrug-resistant Acinetobacter baumannii in China

Abstract

A group of Acinetobacter baumannii confers multidrug resistance, but the molecular epidemiology and multidrug resistance mechanisms are poorly understood. Nineteen isolates were identified, and the antimicrobial susceptibility profile was determined using the disc diffusion method. Then, PCR of 78 kinds of resistance-associated genes were performed. A novel variant of bla ADC gene: bla ADC-67 gene (Genbank accession No. JX169789) was prevalent in all 19 isolates. Moreover, ISAba1 could also provide strong promoter to upregulate the expression of bla ADC67 to confer resistance to beta-lactam. This is the first report of emergence of bla ADC-67 in A. baumannii worldwide, which might confer resistance to beta-lactam. © 2014 Japan Antibiotics Research Association All rights reserve.