RNA Binding Proteins as Potential Therapeutic Targets in Colorectal Cancer

Abstract

RNA-binding proteins (RBPs) are crucial in regulating gene expression in the intestine, and their abnormal activity can lead to colorectal cancer (CRC). This review explores how specific RBPs, such as LIN28, IGF2BPs, Musashi, HuR, and CELF1, contribute to CRC by affecting the stability and translation of key cancer-related genes. These proteins can promote tumor growth, spread, and resistance to treatments. Although targeting RBPs is challenging, recently discovered small molecules can disrupt the harmful interactions, showing promise for new CRC therapies. Further research and development of RBP-targeting agents should lead to better treatment options for CRC patients.