Stereoselective ring contraction of 2,5-diketopiperazines: An innovative approach to the synthesis of promising bioactive 5-membered scaffolds

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Abstract

Ring contraction of 2,5-diketopiperazines by TRAL-alkylation led us to the stereoselective synthesis of original pyrrolidine-2,4-diones, a novel series of promising molecules with moderate anti-proliferative activity on breast cancer cells. © 2010 Elsevier Inc. All rights reserved.

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Coursindel, T., Restouin, A., Dewynter, G., Martinez, J., Collette, Y., & Parrot, I. (2010). Stereoselective ring contraction of 2,5-diketopiperazines: An innovative approach to the synthesis of promising bioactive 5-membered scaffolds. Bioorganic Chemistry, 38(5), 210–217. https://doi.org/10.1016/j.bioorg.2010.05.002

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