Stabilization of exosome-targeting peptides via engineered glycosylation

Abstract

Background: Exosomes show great promise as targeted therapeutic delivery vehicles. Results: A strategy was identified for stabilizing targeting peptides on the surface of exosomes. Conclusion: Glycosylation protects targeting ligands displayed on the surface of exosomes from proteolytic degradation. Significance: Strategies for robust display of targeting peptides will enable targeted delivery of therapeutic exosomes.