Comparison of the Photodynamic Effect of Two Chlorins, Photodithazine and Fotoenticine, in Gliosarcoma Cells

Abstract

The treatment and prognosis of cancers of the nervous system remain unfavorable to the patient, which makes it necessary to study alternative therapies as primary or adjuvant treatments to existing methods. Photodynamic Therapy (PDT) is a method that consists of combining a photosensitizer (PS), a light source at the appropriate wavelength, and molecular oxygen, forming reactive oxygen species (ROS), leading to death in the target cell. The objective of this work was to compare the effects of PDT with two chlorins, Photodithazine (PDZ) and Fotoenticine (FTC), in 9L/lacZ gliosarcoma cell lines. Both chlorins, together with an LED device at 660 nm with a fluence of 10 J/cm², were included in the study. It was observed that the response to therapy depends on the concentration and type of PS used. In addition, PDZ showed a higher quantum yield of singlet oxygen generation than FTC.