The Role of Moisturizer Containing Anti-inflammatory on Skin Hydration in Mild-Moderate Atopic Dermatitis Patients

Abstract

Atopic dermatitis (AD) is a chronic, infammatory skin condition characterized by eczema lesions and dry, itchy skin. Recent guidelines for the management of AD emphasize the importance of using moisturizers in the management of AD. Tis study is a double-blind clinical trial to determine the efectiveness of moisturizers containing anti-infammatory ingredients compared with moisturizers without anti-infammatory ingredients for skin hydration in mild to moderate adult AD patients for 14 days at the Dermatology and Venereology Outpatient Clinic at Dr. Soetomo General Academic Hospital. Tere was a signifcant diference(p < 0.05) at the baseline and day 14 skin hydration values in the experiment group with anti-infammatory ingredients (35.97 ± 6.04–66.06 ± 15.84) and the control group without anti-infammatory ingredients (40.74 ± 10.94–56.12 ± 8.34). After comparison, there was a signifcant diference(p < 0.05) in the skin hydration value between the experiment group and the control group on the 14th day. Tere was also a signifcant diference in the improvement of skin hydration outcomes between both groups (p < 0.05). Te severity of the disease using Scoring Atopic Dermatitis (SCORAD) showed a signifcant diference (p < 0.05) between the experiment group and the control group after 2 weeks of intervention. Te addition of anti-infammatory ingredients in the moisturizer, namely, shea butter, bacterial lysate, allantoin, bisabolol, Phragmites kharka extract, Poria cocos, and Mirabilis jalapa in a moisturizer containing occlusive (dimethicone), humectants (glycerin, saccharide, butylene glycol, and hyaluronic acid), and emollient (shea butter and squalane) was shown to be signifcantly better in improving skin hydration in patients with mild to moderate AD.