Collapsin response mediator protein 5 (CRMP5) induces mitophagy, thereby regulating mitochondrion numbers in dendrites

Abstract

Background: Collapsin response mediator protein 5 (CRMP5) influences neuronal differentiation and dendrite outgrowth during brain development. Results: CRMP5 is partially located in mitochondrial membranes, inducing mitophagy and reducing mitochondrial content of developing dendrites. Conclusion: Control of mitochondrion numbers by CRMP5 inhibits dendrite growth when the axon is growing. Significance: Learning how dendrite growth is regulated by CRMP5 is important for understanding the establishment of neuronal polarization. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.