Re-endothelialization of biological tissue-engineered conduits and scaffold for its potential use in bioprosthesis

Abstract

In vitro and in vivo approaches are currently being used for guided cell repopulation of both biological and synthetic scaffolds. Till now, re- searchers have used different strate- gies to decellularize biological sam- ples such as the use of detergents like SDS, 1× Triton-X and EDTA so- lutions. However, their widespread clinical acceptance is very limited. In the present study, different tissue- engineered biological conduits and scaffolds made from bovine carotid artery (BCA) have been developed using cultured endothelial cells from sheep external jugular vein endothe- lial cells (SEJVECs).