Haemato-biochemical studies on triflupromazine HCL and diazepam premedication for propofol anaesthesia in dogs

Abstract

Aim: To study the effect of Triflupromazine Hcl and diazepam in combination with propofol as preanaesthetic on haematobiochemical parameters in dogs was carried out. Materials and Methods: 16 clinical cases of dogs undergoing different surgical interventions irrespective of age, sex and breed were allotted randomly in to two groups viz., Group A (Triflupromazine Hcl - propofol) and Group B (diazepam - propofol) consisting eight dogs each. Blood samples were collected at different intervals from both the Groups in heparinised syringes as follows: Prior to premedication, fifteen minutes after premedication, fifteen minutes, one hour, six hour, 24 hour and 48 hour after induction with Propofol. The samples were subjected for various hematological and biochemical analysis. Results: Hematology revealed a significant (P 0.05) fall in total erythrocyte count (TEC), packed cell volume (PCV) and haemoglobin (Hb), whereas TLC showed a non significant decrease in both the groups throughout the observation period of 48 hours. In the present study blood glucose level was significantly increased between 15 min to one hour in Group A and 15 min to 6 hours of observation period of the study in Group B. The total plasma protein (TPP), alanine amino transferase (ALT),alkaline phosphatase (AP) and creatinine levels did not differ significantly in both the groups throughout the observation period of 48 hours. Conclusion: Both the anaesthetic combinations were found to be safe and effective with smooth and stress free recovery. However triflupromazine Hcl premedication proved to be better with quick sedative effect, long duration of anaesthesia with less induction dose of propofol and shorter recovery time than diazepam.