Microextraction Techniques for Forensic Drug Analysis in Saliva

Abstract

Forensic drug analysis involves trace level analysis of drugs of abuse and their metabolites in different biological matrices. Saliva has proven to be an alternative matrix over blood, plasma and urine, since collection of saliva is non-invasive, simple, and rapid. Additionally, concentration of drugs in saliva can be correlated to free drug concentration in plasma. Recently, great attention has been paid to develop microextraction techniques for analysis of drugs of abuse in saliva in order to improve quality and sensitivity of analysis. Microextraction techniques are rapid, eco-friendly, inexpensive, simple and offer high extraction efficiencies and enrichment factors. This article focuses on the reviews of procedures and applications of modern microextraction techniques for analysis of drugs of abuse in saliva samples