The Chemistry of Leucomycins. III.1) structure (and Stereochemistry of Leucomycin A32)

Abstract

Leucomycin A3 (I) was oxidized with active manganese dioxide to dehydroleucomycin A3 (II) which was identical with magnamycin B, Acid treatment of I yielded demycarosylleucomycin A3 (VII), which was converted to a triacetate showing mass spectrum M+ (m/e 725), and this observation confirmed the struo ture of I. The diene system of I was assumed to have a trans-trans configuration on the basis of its NMR spectrum, and a full structure of I was proposed with stereochemistry. © 1968, The Pharmaceutical Society of Japan. All rights reserved.