Abstract
Two siblings with a variant form of Fanconi's anemia developed multiple neoplasms after prolonged survival and treatment with androgens. One of the siblings developed two separate oral squamous cell carcinomata, and the other developed acute leukemia and hepatoma. Androgens may have had a carcinogenic role in the appearance of the hepatic neoplasm. There is an increased incidence of neoplasm associated with Fanconi's anemia. This may be related to frequent spontaneous chromosomal aberrations and/or to increased cellular susceptibility to viral transformation. Copyright © 1975 American Cancer Society
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Sarna, G., Tomasulo, P., Lotz, M. J., Bubinak, J. F., Shulman, N. R., & Perry, S. (1975). Multiple neoplasms in two siblings with a variant form of Fanconi’s anemia. Cancer, 36(3), 1029–1033. https://doi.org/10.1002/1097-0142(197509)36:3<1029::AID-CNCR2820360328>3.0.CO;2-5
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