Antiviral activity of 2-amino-4,4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one on poliovirus

Abstract

2-Amino-4,4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one (Phx), which was produced by the reaction of bovine hemoglobin with 2-amino-5-methylphenol, inhibited the proliferation of poliovirus in Vero cells between 0.25 μg/ml and 2 μg/ml with maximal antiviral acitivity at 1 μg/ml. These results suggest that Phx may be useful to prevent the proliferation of poliovirus infection. © 2003 Tohoku University Medical Press.