Changes of Plasma Free Fatty Acids Levels after Oxytocin Administration in Man

Abstract

The effect of buccal administration of oxytocin tablet (100 u) on plasma FFA and TG was studied in healthy subjects. As a result, a decrease of plasma FFA (101 + 27 μEq/l) in the male and an increase (88±34 μEq/l) in the female were detected 60 min after the administration. Changes of plasma TG also suggested a similar tendency both in males and in females. Thus, sex differences in oxytocin effects on plasma FFA were observed after buccal administration, however the rate of change was rather small compared with the data obtained by intramuscular injection of oxytocin (5 u). The effect of oxytocin administration on plasma FFA was preliminarily investigated in female patients with simple obesity, and an increase of plasma FFA was found to be somewhat higher than in normal females. © 1972, The Japan Endocrine Society. All rights reserved.