177Lu-rhPSMA-10.1 Induces Tumor Response in a Patient with mCRPC after PSMA-Directed Radioligand Therapy with 177Lu-PSMA-I&T

Abstract

177Lu-rhPSMA-10.1 is a novel PSMA-targeting radiopharmaceutical that has been optimized in terms of pharmacological and pharmacokinetic properties and may be therefore advantageous in treatment of metastatic castrate-resistant prostate cancer. In this image, we present the case of an 86-year-old man with metastastic castrate-resistant prostate cancer undergoing 177Lu-PSMA-I&T treatment. After initial partial response to radioligand therapy, another 2 treatment cycles resulted in a rising serum PSA level that could be correlated with increasingly PSMA-positive as well as a new bone lesion. Consequently, the patient was changed to 177Lu-rhPSMA-10.1 treatment on a compassionate use basis achieving a renewed tumor response.