Mesothelin expression in pancreatic mucinous cysts

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Abstract

Objectives: Mesothelin (MSLN) is a differentiation antigen found to be overexpressed in intraductal papillary mucinous neoplasms (IPMNs) and is a potential treatment target in pancreatic ductal adenocarcinoma. Methods: From institutional archives, 114 cases of resected pancreatic mucinous cysts were identified, including IPMN and mucinous cystic neoplasm (MCN). Immunohistochemical analysis of MSLN was performed on representative sections. Results: MSLN was seen more frequently in neoplastic epithelial cells from IPMN (39/52; P

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Frank, R., Li, S., Ahmad, N. A., Sepulveda, A. R., & Jhala, N. C. (2014). Mesothelin expression in pancreatic mucinous cysts. American Journal of Clinical Pathology, 142(3), 313–319. https://doi.org/10.1309/AJCPDTTL2I5ECMFG

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