The association of SNP g.880A/G with body weight in F1 cross Dorper x Garut sheep

Abstract

Single nucleotide polymorphism (SNP) in the MC4R gene has been known to be associated with feed intake and growth performance. Our objective was to analyze the association of SNP g.880A>G to birth weight (BW), weaning weight (WW), and 6-month body weight (MW) in F1 cross Dorper x Garut sheep. In forty-one F1 cross Dorper x Garut sheep with phenotypic records, genotyping based on SNP g.880A>G was achieved using the direct-sequencing process. As a result, the homozygous AA genotype was absent in the samples. The frequency of the G allele (90%) was higher than the A allele (10%), followed by GG (80%) and AG (20%) genotypes. The population did not deviate from Hardy Weinberg Equilibrium (p > 0.05) based on SNP g.880A>G. The SNP g.880A>G was significantly associated with MW but not significant in BW and WW. The GG genotype (32.33 ± 4.81 kg) was higher MW than the AG genotype (27.19 ± 1.86 kg). In conclusion, the findings suggested that SNP g.880A>G of the MC4R gene could be used as a potential selection tool for high MW in F1 cross Dorper x Garut sheep.