Enhancement of acetic acid tolerance in Saccharomyces cerevisiae by overexpression of the Haa1 gene, encoding a transcriptional activator

Abstract

Haa1 is a transcriptional activator required for Saccharomyces cerevisiae adaptation to weak acids. Here we show that the constitutive HAA1-overexpressing strain acquired a higher level of acetic acid tolerance. Under conditions of acetic acid stress, the intracellular level of acetic acid was significantly lower in HAA1-overexpressing cells than in the wild-type cells. © 2012, American Society for Microbiology.