A new regulator of the vacuolar H -ATPase in the kidney

Abstract

Xu et al. identify Slc26a11, a novel member of the Slc26 anion exchanger family, as an electrogenic (Cl - ) n /HCO 3 exchanger. Functional characterization of this transporter suggests that Slc26a11 mediates classical electroneutral Cl - /HCO 3- exchange but also exhibits an electrogenic Cl - conductance. In the kidney, Slc26a11 colocalizes with the vacuolar H + -ATPase in intercalated cells, emphasizing the cooperation of the proton pump with chloride transporters. © 2011 International Society of Nephrology.