Ibero-American Consensus for the Management of Liver Metastases of Soft Tissue Sarcoma: Updated Review and Clinical Recommendations

Abstract

Liver metastases from soft tissue sarcoma are very rare. The standard treatment for metastatic sarcoma is primarily based on chemotherapy, often with poor results. However, when metastases are confined to the liver and are amenable to surgery or ablative techniques, radical treatment could be an option, keeping patients disease-free and without the need for systemic cytotoxic treatment for long periods of time, with a positive impact on overall survival. A multidisciplinary working group of experts in sarcoma and liver surgery reviewed the literature and available evidence and developed a set of clinical recommendations to be voted and discussed in the I Ibero-American Consensus on the Management of Metastatic Sarcoma, held during the III Spanish-Portuguese Update Meeting on the Treatment of Sarcomas in May 2024. Herein, the voting results of this meeting and the resulting consensus recommendations are presented, and their applicability, strengths, and limitations are discussed.