P699 Impact of adalimumab's patient support program on clinical outcomes in inflammatory bowel diseases: results from the COMPANION study

Abstract

Background: Adalimumab (ADL) is an anti-TNF biologic therapy indicated for the treatment of inflammatory bowel diseases (IBD), namely Crohn's disease (CD) and ulcerative colitis (UC). Patients re-ceiving ADL in Canada are eligible to enroll in the AbbVie Care patient support program (PSP) which provides them with personalized services including ongoing care coach calls (CCC). In a previous study, IBD patients enrolled in Abbvie Care receiving CCC demon-strated significantly greater persistence and adherence to ADL than patients that did not receive CCC (no-CCC). The objective of this study is to compare the likelihood of achieving clinical remission in a cohort of IBD patients treated with ADL enrolled in the ADL PSP between those who received CCC versus those who did not receive CCC. Method(s): A longitudinal analysis using de-identified aggregate-level data collected through the AbbVie Care PSP was performed. Patients were indexed on the date of their first injection of ADL between January 2010 and October 2015. The ADL PSP database included patient measurements of the Harvey-Bradshaw Index (HBI), a measure of disease severity. To be eligible, patients had to have a baseline HBI measurement 90 days before to 30 days after their index date and have had a follow up HBI measurement 6 to 18 months later. HBI remission (HBI