Ampa receptors exist in tunable mobile and immobile synaptic fractions in vivo

11Citations
Citations of this article
34Readers
Mendeley users who have this article in their library.

Abstract

AMPA receptor (AMPAR) mobility within synapses has been extensively studied in vitro. However, whether similar mobility properties apply to AMPARs in vivo has yet to be determined. Here, we use two-photon fluo-rescence recovery after photobleaching (FRAP) to study AMPAR mobility within individual dendritic spines in live animals using an overexpression vector. We demonstrate the existence of mobile and immobile fractions of AMPARs across multiple cortical regions and layers. Additionally, we find that AMPAR mobility can be al-tered in vivo in response to administration of corticosterone, a condition that mimics exposure to stress.

Author supplied keywords

Cite

CITATION STYLE

APA

Chen, H., Roth, R. H., Lopez-Ortega, E., Tan, H. L., & Huganir, R. L. (2021). Ampa receptors exist in tunable mobile and immobile synaptic fractions in vivo. ENeuro. Society for Neuroscience. https://doi.org/10.1523/ENEURO.0015-21.2021

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free