p53 and metabolism: Old player in a new game

Abstract

Metabolic reprogramming is an integral part of tumor genesis. Tumor suppressor p53 is a well studied transcription factor intimately linked with the control of cell cycle progression and apoptosis. Here, we discuss the emerging role of p53 in the transcriptional regulation of metabolism. This activity is a key component of p53 tumor suppression function. © 2012 Landes Bioscience.