Correction: HIV viremia and T-cell activation differentially affect the performance of glomerular filtration rate equations based on creatinine and cystatin C (PLoS One (2013) 8:12 (e82028) DOI: 10.1371/journal.pone.0082028)

Abstract

After publication of this article [1], it came to light that there were errors in the reported glomerular filtration rate (GFR) estimates. The two-fold purpose of this paper [1] was to 1) compare accuracy and bias of widely used glomerular filtration rate (GFR) estimating equations to a gold-standard GFR measure (iohexol disappearance from plasma) in HIV-positive and HIV-negative volunteers, and 2) to assess factors associated with bias and accuracy of the creatinine-based and cystatin C-based equations. Recently, our co-investigators, who performed the laboratory analyses and calculations for the iohexol GFR, identified a drift that occurred in their measurement of iohexol (prior to this study) that led to an across-the-board underestimation of iohexol concentrations from blood samples, which produced a systematic overestimation of GFR by approximately 10%. This measurement error in this laboratory was described in a publication in 2017[2]. We subsequently repeated the analyses in the PLOS ONE paper using recalibrated (corrected) iohexol GFR values provided here in an updated version of Table 1. (Table Presented).