Crossed Aldol Condensation (CAC) as a Feasible Route for Synthesis of a 1, 2-Unsaturated Carbonyl Compound-1,3 Diphenylpropenone

Abstract

We here report an optimized crossed aldol method for synthesis of 1,2-unsaturated carbonyl compound, 1,3-diphenylpropenone (82-93% yield) rely on alcoholic base assisted condensation of arylmethyl ketone with aromatic aldehydes. The method simply follows the conventional synthetic route however an extraordinary control over various reaction parameters enhance its synthetic practicability. Furthermore, a comparative study has been done to explore the scope for synthesis of 1,3-diphenylpropenone by crossed aldol reaction by solvent assisted method (SAM) and solvent-less method (SLM). Undeniably, solvent-less technique (90-95% yield) hold superiority however tuning of certain reaction parameters, leveled-up solvent assisted crossed aldol reaction, but not to an analogues platform.