κ-carrageenan/poly(ethylene glycol) Based Non-woven Cotton Wound Dressings

Abstract

Kappa carrageenan (КC) is sulfated polysaccharides and can be crosslinked by K+ ions to obtain biohydrogel having a biodegradable nature as well as excellent cytocompatibility. Crosslinking of KC with K+ ions converts it to strong and brittle gel. In that study, non-woven cotton fabric samples (NWCF) were quaternized to achieve QNWCF samples which were then re-treated with different polyethylene glycol/Kappa carrageenan (PEG/КC) blending ratios and crosslinked with K+ ions to achieve КC/PEG/K+/QNWCF wound dressings. The results depict that the appropriate conditions to achieve that dressing is: PEG/KC weight ratio, 0.25%; K+ padding bath concentration, 1%; and immersion time, 10 min. The chemical structure of such dressing was confirmed via FTIR while its morphology was analyzed using scan electron microscope. The sulfadiazine in-vitro releasing from the loaded dressing at pH 7 was investigated. The results confirm that the prepared sulfadiazine loaded dressing has significant antibacterial activities that were remarkably enhanced upon addition of silver nano-particle during the dressing preparation.