Variation of class I HLA antigen expression among platelet density cohorts: A possible index of platelet age?

Abstract

Platelet alloantigens and other surface markers were studied in platelet cohorts of different mean denstiy, using monoclonal and polyclonal probes. High density (HD) platelets expressed 12% more P1(A1) molecules (46,942) than low density (LD) platelets ((41,892). However, LD platelets carried 42% more HLA-A2 molecules (6,267 ± 184) than HD platelets (4,406 ± 232) (P