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Cis-interactions Make Immune Checkpoint Blockade More Trans-parent

Science immunology
DOI: 10.1126/sciimmunol.aba7107
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Abstract

PD-L1:CD80 cis-heterodimer formation preferentially blocks CTLA-4 trans-signaling while allowing CD28-mediated effector T cell activation.

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Khatwani, N., & Pillai, A. B. (2020, January 10). Cis-interactions Make Immune Checkpoint Blockade More Trans-parent. Science Immunology. NLM (Medline). https://doi.org/10.1126/sciimmunol.aba7107

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