Formulation and evaluation of transdermal films of diclofenac sodium

Abstract

Transdermal films of Diclofenac Sodium were formulated by using natural polymer gelatin and plasticizer glycerin in different proportion. The objective of present investigation was to study the effect of varying proportion of plasticizers on gelatin film forming property and study the effect of varying concentration of gelatin on physical, mechanical and in vitro drug release profile. The placebo and medicated films were evaluated for physical and mechanical properties and also medicated films were evaluated for area variation, drug content and percent cumulative drug release. Optimized gelatin to glycerin ratio containing transdermal films shown effective physical and mechanical property along with in vitro drug release profile. The release rate found to follow first order rate and Higuchi model. Primary irritation study shows that the transdermal films are non-irritant.