Abstract
New pyrrolo[1,2-α]quinoxaline-2- or -4-carboxylic acid hydrazide derivatives were synthesized from nitroaniline or 1,2-phenylenediamine, and evaluated in vitro for their antimycobacterial activity as part of a TAACF TB screening program. Two compounds 7c and 13 showed an interesting activity at 6.25 μg/mL against Mycobacterium tuberculosis H37Rv, with a 94 and 100 percentage inhibition, respectively. © 2004 Taylor & Francis Ltd.
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Guillon, J., Reynolds, R. C., Leger, J. M., Guie, M. A., Massip, S., Dallemagne, P., & Jarry, C. (2004). Synthesis and preliminary in vitro evaluation of antimycobacterial activity of new pyrrolo[1,2-a] quinoxaline-carboxylic acid hydrazide derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry, 19(6), 489–495. https://doi.org/10.1080/14756360412331280464
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