A practical and effective asymmetric synthesis of 2-amino-3,3,3-trifluoropropanephosphonic acid

Abstract

A practical and effective Synthesis of 2-amino-3,3,3-trifluoropropanePhosphonic acid of high stereochemical purity was successfully achieved by a base-induced [1,3]-proton shift reaction of the intermediate 2-imino-3,3,3-trifluoropropanePhosphonate. © 2000 John Wiley & Sons, Inc.