B12 deficiency and refractory depressive disorder: A case report

Abstract

Vitamin B12, cyanocobalamin, is implicated in metabolic and neurotrophic functions. Its deficiency is associated with hematological, neurological and psychiatric disorders. Herein we report the case of a patient presenting with refractory depression who improved after the identification and treatment of vitamin B12 deficiency. This report highlights the relevance of considering secondary causes of depression in refractory cases.