APOBEC3G encapsidation into HIV-1 virions: Which RNA is it?

Abstract

APOBEC3G is a cytidine deaminase with potent antiviral activity. The protein deaminates single-stranded DNA but is known to bind cellular and viral RNAs. There is increasing evidence that RNA binding of APOBEC3G is important for packaging into viral particles. However, there is no consensus yet on the type of RNA involved. © 2008 Strebel and Khan; licensee BioMed Central Ltd.