A PROSPECTIVE STUDY ON ANTIMICROBIAL RESISTANCE PATTERN IN INPATIENTS OF GENERAL MEDICINE AND SURGERY DEPARTMENT

Abstract

Wide reports in literatures from different parts of the world revealed that antibiotics resistance is a serious and growing phenol menon in contemporary medicine and has emerged as one of the pre-eminent public health concerns of the 21st century. The purpose of the study is to compare the pattern of antibiotic resistance and to determine whether irrational use of antibiotics is a reason for antibiotic resistance. It was a Prospective observational study conducted multi-disciplinary super specialty tertiary care hospital in South India. All inpatients with either sex admitted to General Medicine and surgery department, including age groups of 18-70 and whose medication profile contains a culture sensitivity test report were included in the study. The outcome of the study was as follows: Klebsiella (25.49%) was the major organism isolated during the Pilot scale study, followed by E. Coli (22.5%), Pseudomonas(12.7%) and Staph. Aureus (19.6%). Amoxicillin showed the best resistance in Klebsiella (52.1%), E. Coli(21.7%), Pseudomonas(13.04%), Staph. Aureus (13.04%). During the prospective study, Klebsiella was the major organism identified in 71.42% of the isolated specimen- sputum. The resistance pattern data of the prospective study revealed that Klebsiella was highly resistant to Amoxicillin (52.1%) followed by E. Coli to Ampicillin (40.05%). Clinical pharmacists have to play an important role in promoting optimal antibiotic prescribing practice among physicians, during their routine visit to wards, which will enable to minimize resistance to antibiotics by the microorganisms.