A Novel Acylated Flavone Glycoside from Andrographis nallamalayana

Abstract

A new acylated flavone glycoside, skullcapflavone I 2′-O-β-D-(6″-E-cinnamoyl) glucopyranoside (1), together with two known flavones, 5,2′-dihydroxy-7-methoxyflavone (2) and 5,2′,6′-trihydroxy-7-methoxyflavone-2′-O-β-D-glucopyranoside (3), and two known labdane diterpenoids, 14-deoxy-11,12-didehydroandrographolide (4) and andrographolide (5) were isolated from the whole plant of Andrographis nallamalayana. Structural elucidation of the new compound, as well as of the known compounds was achieved by various NMR techniques including 1H-1H COSY, HSQC, HMBC and ROESY experiments, ESITOF mass spectrometry, acid hydrolysis and saponification studies.