Bridging the Gap in Understanding Bone Metastasis: A Multifaceted Perspective

3Citations
Citations of this article
18Readers
Mendeley users who have this article in their library.

Abstract

The treatment of patients with advanced cancer poses clinical problems due to the complications that arise as the disease progresses. Bone metastases are a common problem that cancer patients may face, and currently, there are no effective drugs to treat these individuals. Prostate, breast, and lung cancers often spread to the bone, causing significant and disabling health conditions. The bone is a highly active and dynamic tissue and is considered a favorable environment for the growth of cancer. The role of osteoblasts and osteoclasts in the process of bone remodeling and the way in which their interactions change during the progression of metastasis is critical to understanding the pathophysiology of this disease. These interactions create a self-perpetuating loop that stimulates the growth of metastatic cells in the bone. The metabolic reprogramming of both cancer cells and cells in the bone microenvironment has serious implications for the development and progression of metastasis. Insight into the process of bone remodeling and the systemic elements that regulate this process, as well as the cellular changes that occur during the progression of bone metastases, is critical to the discovery of a cure for this disease. It is crucial to explore different therapeutic options that focus specifically on malignancy in the bone microenvironment in order to effectively treat this disease. This review will focus on the bone remodeling process and the effects of metabolic disorders as well as systemic factors like hormones and cytokines on the development of bone metastases. We will also examine the various therapeutic alternatives available today and the upcoming advances in novel treatments.

References Powered by Scopus

The novel zinc finger-containing transcription factor Osterix is required for osteoblast differentiation and bone formation

3085Citations
N/AReaders
Get full text

Bone Marrow, Cytokines, and Bone Remodeling-Emerging Insights into the Pathophysiology of Osteoporosis

1618Citations
N/AReaders
Get full text

Wnt/β-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis

1433Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Balancing the Scales: The Dual Role of Interleukins in Bone Metastatic Microenvironments

1Citations
N/AReaders
Get full text

Immunotherapy in the Battle Against Bone Metastases: Mechanisms and Emerging Treatments

0Citations
N/AReaders
Get full text

Delineating the nexus between gut-intratumoral microbiome and osteo-immune system in bone metastases

0Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Elaasser, B., Arakil, N., & Mohammad, K. S. (2024, March 1). Bridging the Gap in Understanding Bone Metastasis: A Multifaceted Perspective. International Journal of Molecular Sciences. Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/ijms25052846

Readers over time

‘24‘25036912

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 4

57%

Lecturer / Post doc 2

29%

Researcher 1

14%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 1

25%

Pharmacology, Toxicology and Pharmaceut... 1

25%

Nursing and Health Professions 1

25%

Engineering 1

25%

Article Metrics

Tooltip
Mentions
News Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free
0