TiSGeD: A database for tissue-specific genes

Abstract

Summary: The tissue-specific genes are a group of genes whose function and expression are preferred in one or several tissues/cell types. Identification of these genes helps better understanding of tissue-gene relationship, etiology and discovery of novel tissuespecific drug targets. In this study, a statistical method is introduced to detect tissue-specific genes from more than 123 125 gene expression profiles over 107 human tissues, 67 mouse tissues and 30 rat tissues. As a result, a novel subject-specialized repository, namely the tissue-specific genes database (TiSGeD), is developed to represent the analyzed results. Auxiliary information of tissue-specific genes was also collected from biomedical literatures. Availability: http://bioinf.xmu.edu.cn/databases/TiSGeD/index.html. Contact: appo@bioinf.xmu.edu.cn; zhiliang.ji@gmail.com. © The Author(s) 2010. Published by Oxford University Press.