Regio- and Stereoselective Chloro Sulfoximidations of Terminal Aryl Alkynes Enabled by Copper Catalysis and Visible Light

Abstract

By visible-light photoredox catalysis with copper complexes, sulfoximidoyl chlorides add to terminal aryl alkynes to give the corresponding (E)-β-chlorovinyl sulfoximines with exclusive regio- and stereoselectivities in high yields. Two representative products have been characterized by X-ray crystal structure analysis. Radicals appear to be decisive intermediates. As demonstrated by two subsequent reactions, the products can be derivatized. (Figure presented.).