Synthesis and evaluation of 2,4-disubstituted quinazoline derivatives with potent anti- Angiogenesis activities

Abstract

A series of 2,4-disubstituted quinazoline derivatives were designed and synthesized. The biological results showed that most of quinazoline derivatives exhibited potent antiproliferative activities against a panel of three tumor cell lines and a good inhibitory effect against the adhesion and migration of human umbilical vein endothelial cells (HUVECs). Among these compounds, 11d was the most potent agent, that also exhibited the highest anti- Angiogenesis activities in the chick embryo chorioallantoic membrane (CAM) assay.