A series of 2,4-disubstituted quinazoline derivatives were designed and synthesized. The biological results showed that most of quinazoline derivatives exhibited potent antiproliferative activities against a panel of three tumor cell lines and a good inhibitory effect against the adhesion and migration of human umbilical vein endothelial cells (HUVECs). Among these compounds, 11d was the most potent agent, that also exhibited the highest anti- Angiogenesis activities in the chick embryo chorioallantoic membrane (CAM) assay.
Yu, G., Li, Z., Tang, L., & Xiong, Q. (2014). Synthesis and evaluation of 2,4-disubstituted quinazoline derivatives with potent anti- Angiogenesis activities. Molecules, 19(7), 8916–8932. https://doi.org/10.3390/molecules19078916