Abstract
Background: The NLRP3 inflammasome is a critical component of the innate immune system, and its malfunction contributes to the pathogenesis of inflammatory diseases. Results: Nitrostyrene specifically inhibits NLRP3 activation. Conclusion: Nitrostyrene blocks the assembly of NLRP3 inflammasome by inhibiting NLRP3 ATPase activity. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
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CITATION STYLE
He, Y., Varadarajan, S., Muñoz-Planillo, R., Burberry, A., Nakamura, Y., & Núñez, G. (2014). 3,4-Methylenedioxy-β’-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome. Journal of Biological Chemistry, 289(2), 1142–1150. https://doi.org/10.1074/jbc.M113.515080
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