A review on therapeutic effect of non bio-fermented and bio-fermented product of various herbal drugs in the treatment of gastric ulcer

Abstract

The plan of this study is to find out the effect of several non Bio-fermented and Bio-fermented product of the various herbal drugs in health promotion. Many traditional medicines were shown to have anti-ulcer activity by using aqueous and non–aqueous solvents and probiotics. Micro-organisms such as Weissella cibaria, Saccharomyces cerevisiae, Bifidobacterium, lactobacillus and Streptococcus thermophilus which are already use in bio-fermentation of herbal medicines. Non-steroidal anti-inflammatory drugs have painkiller, anti-inflammatory as well as anti-pyretic properties. These drugs have a side effect of gastric ulcers by inhibition of COX enzymes and reduce the prostaglandin secretion resulting in luminal aggression that induces stomach ulcers. Various Non-steroidal anti-inflammatory drugs inhibit both enzymes COX-1 and COX-2 further categorized as non-selective inhibitors. Stress, eating fast food, consuming more alcohol and busy lifestyles are common causes of gastric ulcers. Probiotics are good for the intestine and stomach because they increase the secretion of prostaglandin (PGE-2) in the mucus membrane, changes the pH of intestine and improve the digestion in the gastro intestinal tract. This study focuses the bio-fermentation of herbal medicines through various microbes. It also suggests that anti-ulcer activity of bio-fermented products is more dynamic than for non bio-fermented products. Here, we suggest that bio-fermented product of herbals shows protective effects in gastric ulcers.